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UPDATE: Added a compatibility patch for people using the new Dead Money DLC. This is mostly for food items right now, but may be expanded later.
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Playable Ghoul allows the Courier to roam the Mojave Wasteland as a Ghoul. This is more than just a simple texture/race mod, and offers some effects:

-2 Strength (STR)
-2 Charisma (CHR)
+2 Endurance (END)

Ghouls are resistant to most chems, including alcohol. The effect of chems lasts only 1/4th as long as normal, but the chance of addiction is only 1/10th of normal. The only exceptions to the above are Rocket and Ultrajet. RadAway and Rad-X will cause physical damage to a Ghoul if used. Certain other substances will still work as normal on Ghouls, particularly the special variants of Nuka-Cola. Additionally, Irradiated variants of alcohol have the same effect duration as normal.

Radiation levels in a Ghoul's body decrease (or more accurately, the level which is considered "normal" moves up) over time, at a rate of 1 Rad/ 10s.

Radiation Poisoning has positive as well as negative effects on Ghouls:

Minor - +1 END, +2 HP/s, -1 Rad/s
Advanced - +2 END, -1 INT, +4 HP/s, -2 Rad/s
Critical - +3 END, -2 INT, -1 STR, +6 HP/s, -4 Rad/s
Deadly - +4 END, -3 INT, -2 STR, +8 HP/s, -6 Rad/s
Fatal - +4 END, -3 INT, -2 STR, +8 HP/s, -30 Rad/s

Ghouls do not die from Fatal Rad Poisoning.

Finally, Ghouls have access to a Ghoul-only Perk: Feral Affinity. This perk ensures Feral Ghouls will not attack the Courier unless the Courier attacks first.

Please remember that this mod hasn't been fully playtested for balance. I would appreciate any feedback you can offer.